Pomella™ Pomegranate Extract

The Pomella™ Difference

Not all pomegranate extracts are equal. Many generic options vary in purity, lack standardisation, and show little clinical validation.
Pomella™ stands apart as the only pomegranate extract proven to generate bioactive urolithins, ensuring true systemic activity.

Pomella™ delivers:
• Clinically verified urolithin production for systemic antioxidant and anti-inflammatory effects
• Consistent bioavailability and safety demonstrated in human trials
• Documented improvements in gut diversity, skin health, and cardiovascular balance

Pomella™ is more than an extract – it’s a bio-transformative nutrient designed to work through the gut axis, influencing skin, heart, and brain vitality from within.

Mechanisms of Action

Gut-Axis Support
• Polyphenol Metabolism: Gut flora convert punicalagins into urolithins, activating gut-to-brain, gut-to-heart, and gut-to-skin pathways.
• Microbiome Diversity: Promotes beneficial strains such as Akkermansia muciniphila and Faecalibacterium.
• Barrier Integrity: Strengthens mucosal layers and tight-junction resilience.
• Systemic Signalling: Boosts short-chain fatty acids (acetate, propionate) to regulate inflammation and metabolism.

Systemic Efficacy
• Ellagitannins → Urolithins: Gut-derived urolithins circulate systemically, driving antioxidant and anti-ageing activity.
• SCFA Modulation: Increases acetate and propionate, supporting gut barrier function and systemic balance.
• Antioxidant & Anti-Glycative Effects: Protects fibroblasts from UV damage, reduces collagen cross-linking, and prevents AGE formation.

Proven Benefits

Antioxidant Defence & Healthy Ageing
Pomella™ helps combat oxidative stress – a key driver of cellular ageing – by neutralising free radicals and supporting mitochondrial health.

Cardiovascular & Metabolic Health
Clinical research shows Pomella™ supports healthy cholesterol, reduces oxidised LDL, and lowers key inflammation markers such as hs-CRP and homocysteine. It may also help regulate blood glucose and HbA1c levels in metabolic conditions.

Skin Health & Beauty from Within
In clinical studies, 250 mg daily for 4 weeks resulted in:
• A 6.2 % reduction in wrinkle severity (vs ~1 % with placebo)
• Enhanced collagen protection and UV-resistance
• Increased production of beneficial SCFAs linked to gut-skin balance

Brain & Cognitive Support
Pomella™ polyphenols and their metabolites cross the blood-brain barrier, protecting neurons from oxidative damage and supporting cognitive longevity.

Gut & Microbiome Balance
• Encourages growth of Akkermansia muciniphila and other beneficial strains
• Boosts SCFA production (acetate and propionate)
• Supports digestive comfort, mucosal health, and balanced gut flora

Backed by Science

• Double-blind, placebo-controlled studies confirm measurable improvements in skin elasticity, gut microbiome composition, and metabolic balance.
• Cardiovascular trials show reductions in oxidative and inflammatory biomarkers.
• In-vitro and in-vivo research demonstrate antioxidant, anti-inflammatory, and anti-glycation activity.

Quality You Can Trust

• Patented ingredient with full global traceability
• Clinically validated in published human trials
• Vegan, allergen-free, and naturally potent
• Supported by Medford’s practitioner-grade quality standards

Pomella™ delivers a standardised, clinically validated pomegranate extract proven to generate beneficial urolithins and short-chain fatty acids – key metabolites that influence the gut-brain-skin-heart axis.

By supporting oxidative balance, vascular function, and microbiome health, Pomella™ provides an evidence-based foundation for comprehensive wellbeing and graceful ageing.

Pomella™ – the science-backed power of pomegranate at the heart of Medford’s Gut Health Protocol.

Ingredients

Pack Size: 60

Each vegetable capsule contains: Pomella® Pomegrante extract Punica granatum (fruit) 150 mg

Other Ingredients: Microcrystalline cellulose; vegetable capsule.

Pomella^™ is a U.S. registered trademark of Verdure Sciences Inc.
Protected by US Patent 12,390,504